Wild lettuce Bark Dosage Guide
Wild Lettuce, sometimes called “Opium Lettuce,” is a sedative herb historically used for pain relief, sleep, and relaxation. It contains lactones that calm the nervous system without narcotic properties.
We recommend starting with about 500mg of our extract. Take up to 2–3x daily as needed.
The Pharmacology of Wild lettuce
Wild Lettuce’s active constituents — lactucin, lactucopicrin, and sesquiterpene lactones — act as non-opioid analgesics and CNS depressants that modulate adenosine and acetylcholine systems.
It’s often described as a botanical bridge between mild opiates and valerian, providing deep relaxation and pain relief without addiction risk.
Experience Profile
Heavy-body calm and sleepiness
Relief from restlessness, nerve tension, or pain
Dream enhancement and deep sleep
Pairs beautifully with California Poppy or Amanita for nighttime rituals
Common Misconceptions
“Wild Lettuce is an opiate.”
It’s not. It contains no opioids — its effects are from lactones that calm the CNS naturally.
“It’s too sedating.”
At the right dose, it provides comfort without sedation, allowing restful calm without total drowsiness.